Microenvironmental stiffness mediates cytoskeleton re-organization in chondrocytes through laminin-FAK mechanotransduction

• Main Authors: Chenchen Zhou (Author), Mengmeng Duan (Author), Daimo Guo (Author), Xinmei Du (Author), Demao Zhang (Author), Jing Xie (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Microenvironmental biophysical factors play a fundamental role in controlling cell behaviors including cell morphology, proliferation, adhesion and differentiation, and even determining the cell fate. Cells are able to actively sense the surrounding mechanical microenvironment and change th...