Inflammasome-Independent NALP3 Contributes to High-Salt Induced Endothelial Dysfunction

• Main Authors: Hui Fu (Author), Ji-Kuai Chen (Author), Wen-Jie Lu (Author), Yu-Jie Jiang (Author), Yuan-Yuan Wang (Author), Dong-Jie Li (Author), Fu-Ming Shen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Backgrounds and Aims: Na+ is an important nutrient and its intake, mainly from salt (NaCl), is essential for normal physiological function. However, high salt intake may lead to vascular injury, independent of a rise in blood pressure (BP). Canonical NALP3 inflammasome activation is a caspase-1 medi...