Localization of ^99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses

• Main Authors: Aikaterini Kaloudi (Author), Emmanouil Lymperis (Author), Panagiotis Kanellopoulos (Author), Beatrice Waser (Author), Marion de Jong (Author), Eric P. Krenning (Author), Jean Claude Reubi (Author), Berthold A. Nock (Author), Theodosia Maina (Author)
• Format: Book
• Published: MDPI AG, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The overexpression of gastrin-releasing peptide receptors (GRPRs) in frequently occurring human tumors has provided the opportunity to use bombesin (BBN) analogs as radionuclide carriers to cancer sites for diagnostic and therapeutic purposes. We have been alternatively exploring human GRP motifs of...