Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1

• Main Authors: Weimin Chen (Author), Madhu Pandey (Author), Hong Sun (Author), Andrea Rolong (Author), Mingyan Cao (Author), Dengfeng Liu (Author), Jihong Wang (Author), Lingmin Zeng (Author), Alan Hunter (Author), Shihua Lin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T-cell-mediated immunotherapy has generated much excitement after the success of therapeutic biologics targeting immune checkpoint molecules. Bispecific antibodies (BsAbs) that recognize two antigen targets are a fast-growing class of biologics offering promising clinical benefits for cancer immunot...