Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1

• Hauptverfasser: Weimin Chen (Verfasst von), Madhu Pandey (Verfasst von), Hong Sun (Verfasst von), Andrea Rolong (Verfasst von), Mingyan Cao (Verfasst von), Dengfeng Liu (Verfasst von), Jihong Wang (Verfasst von), Lingmin Zeng (Verfasst von), Alan Hunter (Verfasst von), Shihua Lin (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

T-cell-mediated immunotherapy has generated much excitement after the success of therapeutic biologics targeting immune checkpoint molecules. Bispecific antibodies (BsAbs) that recognize two antigen targets are a fast-growing class of biologics offering promising clinical benefits for cancer immunot...