Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

• Main Authors: Víctor Mangas-Sanjuán (Author), María Pleguezuelos-Villa (Author), Matilde Merino-Sanjuán (Author), Mª Jesús Hernández (Author), Amparo Nácher (Author), Alfredo García-Arieta (Author), Daniel Peris (Author), Irene Hidalgo (Author), Lluís Soler (Author), Marta Sallan (Author), Virginia Merino (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was to compare the microstructure-defining physical parameters of different batches of a...