Electrophysiological responses to seizurogenic compounds dependent on E/I balance in human iPSC-derived cortical neural networks

Construction of in vitro functional assay systems using human-induced pluripotent stem cells (iPSCs) as indicators for evaluating seizure liability of compounds has been anticipated. Imbalance of excitation/inhibition (E/I) inputs triggers seizure; however, the appropriate ratio of E/I neurons for e...

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Main Authors: R. Yokoi (Author), T. Shigemoto-Kuroda (Author), N. Matsuda (Author), A. Odawara (Author), I. Suzuki (Author)
Format: Book
Published: Elsevier, 2022-02-01T00:00:00Z.
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Call Number: A1234.567
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