Electrophysiological responses to seizurogenic compounds dependent on E/I balance in human iPSC-derived cortical neural networks
Construction of in vitro functional assay systems using human-induced pluripotent stem cells (iPSCs) as indicators for evaluating seizure liability of compounds has been anticipated. Imbalance of excitation/inhibition (E/I) inputs triggers seizure; however, the appropriate ratio of E/I neurons for e...
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Format: | Book |
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Elsevier,
2022-02-01T00:00:00Z.
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Internet
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A1234.567 |
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