Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress

• Main Authors: Shi-Meng Liu (Author), Ya-Rong Zhang (Author), Yao Chen (Author), Deng-Ren Ji (Author), Jie Zhao (Author), Su Fu (Author), Mo-Zhi Jia (Author), Yan-Rong Yu (Author), Chao-Shu Tang (Author), Wei Huang (Author), Ye-Bo Zhou (Author), Yong-Fen Qi (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular calcification (VC) is a common pathophysiological process of chronic kidney disease (CKD). Sirtuin 3 (Sirt3), a major NAD⁺-dependent protein deacetylase predominantly in mitochondria, is involved in the pathogenesis of VC. We previously reported that intermedin (IMD)...