Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress

• Autori principali: Shi-Meng Liu (Autore), Ya-Rong Zhang (Autore), Yao Chen (Autore), Deng-Ren Ji (Autore), Jie Zhao (Autore), Su Fu (Autore), Mo-Zhi Jia (Autore), Yan-Rong Yu (Autore), Chao-Shu Tang (Autore), Wei Huang (Autore), Ye-Bo Zhou (Autore), Yong-Fen Qi (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Vascular calcification (VC) is a common pathophysiological process of chronic kidney disease (CKD). Sirtuin 3 (Sirt3), a major NAD⁺-dependent protein deacetylase predominantly in mitochondria, is involved in the pathogenesis of VC. We previously reported that intermedin (IMD)...