Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation

• Main Authors: Carina Heydt (Author), Christina B. Wölwer (Author), Oscar Velazquez Camacho (Author), Svenja Wagener-Ryczek (Author), Roberto Pappesch (Author), Janna Siemanowski (Author), Jan Rehker (Author), Florian Haller (Author), Abbas Agaimy (Author), Karl Worm (Author), Thomas Herold (Author), Nicole Pfarr (Author), Wilko Weichert (Author), Thomas Kirchner (Author), Andreas Jung (Author), Jörg Kumbrink (Author), Wolfgang Goering (Author), Irene Esposito (Author), Reinhard Buettner (Author), Axel M. Hillmer (Author), Sabine Merkelbach-Bruse (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated for their ability to detect gene fusions in eight cell lin...