Plasma ST6GAL1 regulates IgG sialylation to control IgA nephropathy progression

• Main Authors: Youxia Liu (Author), Huyan Yu (Author), Sijing Wu (Author), Xia Yang (Author), Congcong Cao (Author), Fanghao Wang (Author), Junya Jia (Author), Tiekun Yan (Author)
• Format: Book
• Published: SAGE Publishing, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Our previous study revealed that plasma levels of a-2,6-sialyltransferase 1 (ST6GAL1) were increased in patients with IgA nephropathy (IgAN). ST6GAL1 catalyzes terminal sialylation of IgG to shift the antibody effector function to the anti-inflammatory pattern. However, the role of plasm...