Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function

• Main Authors: Rumeng Yao (Author), Ruiyuan Pan (Author), Chao Shang (Author), Xiaoheng Li (Author), Jinbo Cheng (Author), Jiangping Xu (Author), Yunfeng Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central nervous system, and its expression is greatly increased when microglia are activated. However, the role and mechanism of this protein in microglial activation is not well characterized. In this study, we investi...