Protective effect of hypoxia inducible factor-1α gene therapy using recombinant adenovirus in cerebral ischaemia-reperfusion injuries in rats

• Main Authors: Ya-Qi Li (Author), Zhi-Rong Hui (Author), Tao Tao (Author), Kang-Yu Shao (Author), Zhi Liu (Author), Min Li (Author), Li-Ling Gu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Hypoxia-inducible factor-1α (HIF-1α)-induced genes can improve blood circulation. Objective To investigate brain protective effect of recombinant adenovirus-mediated HIF-1α (AdHIF-1α) expression and its mechanism. Materials and methods Male SD rats were used to establish focal cerebral ischa...