Spatial heterogeneity and organization of tumor mutation burden with immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer

• Hoofdauteurs: Hongming Xu, Ph.D (Auteur), Jean René Clemenceau (Auteur), Sunho Park, Ph.D (Auteur), Jinhwan Choi, M.S (Auteur), Sung Hak Lee, M.D (Auteur), Tae Hyun Hwang, Ph.D (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2022-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background: High tumor mutation burden (TMB-H) could result in an increased number of neoepitopes from somatic mutations expressed by a patient's own tumor cell which can be recognized and targeted by neighboring tumor-infiltrating lymphocytes (TILs). Deeper understanding of spatial heterogenei...