Spatial heterogeneity and organization of tumor mutation burden with immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer

• Main Authors: Hongming Xu, Ph.D (Author), Jean René Clemenceau (Author), Sunho Park, Ph.D (Author), Jinhwan Choi, M.S (Author), Sung Hak Lee, M.D (Author), Tae Hyun Hwang, Ph.D (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: High tumor mutation burden (TMB-H) could result in an increased number of neoepitopes from somatic mutations expressed by a patient's own tumor cell which can be recognized and targeted by neighboring tumor-infiltrating lymphocytes (TILs). Deeper understanding of spatial heterogenei...