Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway

• Main Authors: Yuandong Shao (Author), Lei Sun (Author), Guihe Yang (Author), Wenchao Wang (Author), Xiaoyang Liu (Author), Ting Du (Author), Feifei Chen (Author), Xingzhi Jing (Author), Xingang Cui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc degeneration (IVDD). Icariin (ICA) is the major active ingredient of Herba Epimedii and has various biological activities such as anti-inflammatory and antioxidant, which is used to treat many degenera...