Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function

• Main Authors: Xiyuan Ba (Author), Chenqiu Ran (Author), Wenjun Guo (Author), Jing Guo (Author), Qian Zeng (Author), Tao Liu (Author), Wuping Sun (Author), Lizu Xiao (Author), Donglin Xiong (Author), Yelan Huang (Author), Changyu Jiang (Author), Yue Hao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxytocin (OT) and its receptor are promising targets for the treatment and prevention of the neuropathic pain. In the present study, we compared the effects of a single and continuous intrathecal infusion of OT on nerve injury-induced neuropathic pain behaviours in mice and further explore the mecha...