Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts

• Main Authors: Mahoko Asayama (Author), Junko Kurokawa (Author), Kiyoshi Shirakawa (Author), Hisashi Okuyama (Author), Toshiki Kagawa (Author), Jun-ichi Okada (Author), Seiryo Sugiura (Author), Toshiaki Hisada (Author), Tetsushi Furukawa (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K+ channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may likewise pose significant arrhythmia risk. hERG activators...