Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models.

• Main Authors: Carly R Perry (Author), Melissa L Burke (Author), Deborah J Stenzel (Author), Donald P McManus (Author), Grant A Ramm (Author), Geoffrey N Gobert (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathological outcomes of schistosomiasis are largely dependent on the molecular and cellular mechanisms of the host immune response. In this study, we investigated the contribution of variations in host gene expression to the contrasting hepatic pathology observed between two inbred mouse strain...