OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus

• Main Authors: Natalia Castaño-Rodríguez (Author), Georgia L. Popple (Author), Gloria Liliana Porras-Hurtado (Author), José Luis Cardona-Deazza (Author), Juan José Montoya-Martinez (Author), Antonio Javier Cadavid-Velez (Author), Héctor William Toro-Hidalgo (Author), Alba Ruth Cobo-Alvarado (Author), Ofelia del Socorro Hincapié-Rincón (Author), Stephen M. Riordan (Author), Nadeem O. Kaakoush (Author)
• Format: Book
• Published: BMC, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract OPCML hypermethylation is considered a promising cancer biomarker. We examined methylation levels in the first exon of OPCML in two patient cohorts within the esophageal adenocarcinoma and gastric adenocarcinoma cascades and in a range of cell-lines using a custom PyroMark CpG assay. Methyl...