Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo

• Main Authors: Xin Yao (Author), QunYing Mao (Author), Yajing Li (Author), Chunsheng Hao (Author), LianLian Bian (Author), Pan Chen (Author), Fan Gao (Author), Xing Wu (Author), WeiWei Lu (Author), Qiang Gao (Author), XiuLing Li (Author), Zhenglun Liang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutralizing antibodies (NTAbs) is a major criterion for evaluation the immunogenicity of many vaccines, for example, poliovirus and EV71 vaccine. Here, we firstly discovered that polyclonal antibodies induced by inactivated CVA16 vaccine and lived CVA16 virus have poor ability to neutralize circula...