CYP3A genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study

• Главные авторы: Laurence McEvoy (Автор), Joanne Cliff (Автор), Daniel F Carr (Автор), Andrea Jorgensen (Автор), Rosemary Lord (Автор), Munir Pirmohamed (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Предметы: article
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Background: Taxane-induced peripheral neuropathy (TIPN) is an important cause of premature treatment cessation and dose-limitation in cancer therapy. It also reduces quality of life and survivorship in affected patients. Genetic polymorphisms in the CYP3A family have been investigated but the findin...