Optimization and Validation of a Chromatographic Method for the Quantification of Isoniazid in Urine of Tuberculosis Patients According to the European Medicines Agency Guideline

• Main Authors: Pooja Mishra (Author), Jaume Albiol-Chiva (Author), Devasish Bose (Author), Abhilasha Durgbanshi (Author), Juan Peris-Vicente (Author), Samuel Carda-Broch (Author), Josep Esteve-Romero (Author)
• Format: Book
• Published: MDPI AG, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoniazid is a drug that is widely used against tuberculosis. However, it shows high interpatient variability in metabolism kinetics and clinical effect, which complicates the prescription of the medication and jeopardizes the success of the therapy. Therefore, in a specific patient, the pharmacokin...