Formulation design and characterization of a non-ionic surfactant based vesicular system for the sustained delivery of a new chondroprotective agent

• Main Authors: Muhammad Imran Khan (Author), Asadullah Madni (Author), Saeed Ahmad (Author), Muhammad Ahmad Mahmood (Author), Mubashar Rehman (Author), Muhammad Ashfaq (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diacerein is used for symptomatic relief and cartilage regeneration in osteoarthritis. Due to gastrointestinal side effects, poor aqueous solubility and low bioavailability, its clinical usage has been restricted. The objective of the present study was to enhance its dissolution profile and to attai...