Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway

• Main Authors: Ke Liu (Author), Lulu Li (Author), Zhijun Liu (Author), Gang Li (Author), Yanqing Wu (Author), Xingjun Jiang (Author), Mengdie Wang (Author), Yanmin Chang (Author), Tingting Jiang (Author), Jianheng Luo (Author), Jiahui Zhu (Author), Hongge Li (Author), Yong Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this resear...