Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

• Hoofdauteurs: Mengen Zhang (Auteur), Jingyi Zhu (Auteur), Yun Zheng (Auteur), Rui Guo (Auteur), Shige Wang (Auteur), Serge Mignani (Auteur), Anne-Marie Caminade (Auteur), Jean-Pierre Majoral (Auteur), Xiangyang Shi (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2018-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells. In this work, we covalently conjugated DOX onto the periphery of partially acetylated and...