Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

• Main Authors: Mengen Zhang (Author), Jingyi Zhu (Author), Yun Zheng (Author), Rui Guo (Author), Shige Wang (Author), Serge Mignani (Author), Anne-Marie Caminade (Author), Jean-Pierre Majoral (Author), Xiangyang Shi (Author)
• Format: Book
• Published: MDPI AG, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells. In this work, we covalently conjugated DOX onto the periphery of partially acetylated and...