Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia

• Main Authors: Enrico Gugliandolo (Author), Marika Cordaro (Author), Rosalba Siracusa (Author), Ramona D'Amico (Author), Alessio Filippo Peritore (Author), Tiziana Genovese (Author), Daniela Impellizzeri (Author), Rosanna Di Paola (Author), Rosalia Crupi (Author), Salvatore Cuzzocrea (Author), Roberta Fusco (Author)
• Format: Bog
• Udgivet: MDPI AG, 2020-09-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Background: Intestinal ischemic reperfusion (I/R) injury is associated with a high mortality rate; this condition is also related to significant endotoxemia and systemic inflammation. The preservation of tissue perfusion and a sufficient blood flow are required to deliver nutrients and oxygen, prese...