Alpha 2-adrenoceptor participates in anti-hyperalgesia by regulating metabolic demand

• Main Authors: Ke Zhang (Author), Yu-Qing Ren (Author), Yan Xue (Author), Dongxia Duan (Author), Tong Zhou (Author), Ying-Zhuo Ding (Author), Xiang Li (Author), Wan-Kun Gong (Author), Jiao-Qiong Guan (Author), Le Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The α2-adrenoceptor agonist dexmedetomidine is a commonly used drug for sedatives in clinics and has analgesic effects; however, its mechanism of analgesia in the spine remains unclear. In this study, we systematically used behavioural and transcriptomic sequencing, pharmacological intervention, ele...