Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression

Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression

SUMMARY Tp53 mutations are common in human prostate cancer (CaP), occurring with a frequency of ∼30% and ∼70% in localized and metastatic disease, respectively. In vitro studies have determined several common mutations of Tp53 that have specific gain-of-function properties in addition to loss of fun...

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Main Authors: Ruth L. Vinall (Author), Jane Q. Chen (Author), Neil E. Hubbard (Author), Shola S. Sulaimon (Author), Michael M. Shen (Author), Ralph W. DeVere White (Author), Alexander D. Borowsky (Author)
Format: Book
Published: The Company of Biologists, 2012-11-01T00:00:00Z.
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3rd Floor Main Library

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