Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages

• Main Authors: Shuo Zheng (Author), Apparao B. Kummarapurugu (Author), Gamze B. Bulut (Author), Aamer Syed (Author), Le Kang (Author), Judith A. Voynow (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Neutrophil elastase (NE), a major inflammatory mediator in chronic obstructive pulmonary disease (COPD) airways, impairs macrophage function, contributing to persistence of airway inflammation. We hypothesized that NE activates a novel mechanism of macrophage‐induced inflammation: release o...