Mutations in the voltage sensors of domains I and II of Nav1.5 that are associated with arrhythmias and dilated cardiomyopathy generate gating pore currents

Mutations in the voltage sensors of domains I and II of Nav1.5 that are associated with arrhythmias and dilated cardiomyopathy generate gating pore currents

Voltage gated sodium channels (Nav) are transmembrane proteins responsible for action potential initiation. Mutations mainly located in the voltage sensor domain (VSD) of Nav1.5, the cardiac sodium channel, have been associated with the development of arrhythmias combined with dilated cardiomyopathy...

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Main Authors: Adrien eMoreau (Author), Pascal eGosselin-Badaroudine (Author), Mohamed eBoutjdir (Author), Mohamed eChahine (Author)
Format: Book
Published: Frontiers Media S.A., 2015-12-01T00:00:00Z.
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