Synthesis, anticancer activities and experimental-theoretical DNA interaction studies of 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile

• Main Authors: Taniris Cafiero Braga (Author), Marina Magalhães Silva (Author), Eduarda O.O. Nascimento (Author), Edjan Carlos Dantas da Silva (Author), Yuri de Freitas Rego (Author), Mullicka Mandal (Author), Zaqueu Alves de Souza (Author), Ana Lúcia Tasca Góis Ruiz (Author), João Ernesto de Carvalho (Author), Felipe Terra Martins (Author), Isis Martins Figueiredo (Author), Thiago Mendonça de Aquino (Author), Cleiton Moreira da Silva (Author), Bhagirath Mandal (Author), Goutam Brahmachari (Author), Josué Carinhanha Caldas Santos (Author), Ângelo de Fátima (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Twenty chromenes were synthesized with good to excellent yields (70-96%). From the series of chromenes herein tested, compounds 14, 12, 15, 16, 17, 18, and 20 were the most potent throughout the cancer human cell lines tested. In general, the para-position electron-withdrawing substituents on the ph...