Cefiderocol Protects against Cytokine- and Endotoxin-Induced Disruption of Vascular Endothelial Cell Integrity in an In Vitro Experimental Model

• Main Authors: Dagmar Hildebrand (Author), Jana Böhringer (Author), Eva Körner (Author), Ute Chiriac (Author), Sandra Förmer (Author), Aline Sähr (Author), Torsten Hoppe-Tichy (Author), Klaus Heeg (Author), Dennis Nurjadi (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The severe course of bloodstream infections with Gram-negative bacilli can lead to organ dysfunctions and compromise the integrity of the vascular barrier, which are the hallmarks of sepsis. This study aimed to investigate the potential effect of cefiderocol on the barrier function of vascular endot...