Therapeutic drug monitoring of methotrexate after its administration in high doses for osteosarcoma treatment in children

• Main Authors: A. M. Strizhevskaya (Author), E. G. Golovnya (Author), I. S. Kuleshova (Author), A. Z. Dzampaeva (Author), V. N. Baykova (Author)
• Formato: Livro
• Publicado em: LLC "Publisher OKI", 2020-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

In children oncology high doses of methotrexate (HD Mtx) use for treatment of osteosarcoma, acute lymphoblastic leukemia and many others tumors. Due to high intra- and interindividual Mtx pharmacokinetic variability it is essential perform monitoring its concentration in the saliva. The most dangero...