Tumor Cell-Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation

• Main Authors: Miaomiao Zhang (Author), Xiaopeng Guo (Author), Yue Gao (Author), Dong Lu (Author), Wenjian Li (Author)
• 格式: 图书
• 出版: SAGE Publishing, 2018-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PK...