Reduction of oxidative stress suppresses poly-GR-mediated toxicity in zebrafish embryos

• मुख्य लेखकों: Fréderike W. Riemslagh (लेखक), Rob F. M. Verhagen (लेखक), Esmay C. van der Toorn (लेखक), Daphne J. Smits (लेखक), Wim H. Quint (लेखक), Herma C. van der Linde (लेखक), Tjakko J. van Ham (लेखक), Rob Willemsen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The hexanucleotide (G4C2)-repeat expansion in the C9ORF72 gene is the most common pathogenic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This repeat expansion can be translated into dipeptide repeat proteins (DPRs), and distribution of the poly-GR DPR correlates w...