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Complement-Mediated Thrombotic Microangiopathy and Spontaneous Splenic Rupture Associated With Cytomegalovirus Infection

This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of v...

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Bibliographic Details
Main Authors: Sadia Shabir MD (Author), Caleb T Spencer MD (Author), Arooj Tabassum MD (Author), Arjun Chandra MD (Author), Wasef Sayeh MD (Author), Fadi Safi MD (Author), Shahab Ud din MD (Author)
Format: Book
Published: SAGE Publishing, 2023-05-01T00:00:00Z.
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Summary:This is a case report of a previously healthy female patient with complement-mediated thrombotic microangiopathy (TMA) caused by a systemic cytomegalovirus infection that was successfully treated with plasmapheresis, steroids, and parenteral valganciclovir. Complement-mediated TMA is the result of various genetic mutations leading to complement abnormalities with overactivation of alternate complement pathway in response to a triggering infection. She also had splenic rupture without splenomegaly and was managed successfully without splenectomy.
Item Description:2324-7096
10.1177/23247096231172467

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