Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania

• 主要な著者: Siana Nkya (著者), Liberata Mwita (著者), Josephine Mgaya (著者), Happiness Kumburu (著者), Marco van Zwetselaar (著者), Stephan Menzel (著者), Gaston Kuzamunu Mazandu (著者), Raphael Sangeda (著者), Emile Chimusa (著者), Julie Makani (著者)
• フォーマット: 図書
• 出版事項: BMC, 2020-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one individual to another. Most research has focused on co...