A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies

• Main Authors: Oscar Mejias-Gomez (Author), Andreas V. Madsen (Author), Kerstin Skovgaard (Author), Lasse E. Pedersen (Author), J. Preben Morth (Author), Timothy P. Jenkins (Author), Peter Kristensen (Author), Steffen Goletz (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe human immune system uses antibodies to neutralize foreign antigens. They are composed of heavy and light chains, both with constant and variable regions. The variable region has six hypervariable loops, also known as complementary-determining regions (CDRs) that determine antibody divers...