Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation.

• Main Authors: Yegnasew Takele (Author), Emebet Adem (Author), Susanne Ursula Franssen (Author), Rebecca Womersley (Author), Myrsini Kaforou (Author), Michael Levin (Author), Ingrid Müller (Author), James Anthony Cotton (Author), Pascale Kropf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis (VL) is a neglected tropical disease that causes substantial morbidity and mortality and is a growing health problem in Ethiopia, where this study took place. Most individuals infected with Leishmania donovani parasites will stay asymptomatic, but some develop VL that, if left...