An innovative data analysis strategy for accurate next-generation sequencing detection of tumor mitochondrial DNA mutations

• Main Authors: Shanshan Guo (Author), Kaixiang Zhou (Author), Qing Yuan (Author), Liping Su (Author), Yang Liu (Author), Xiaoying Ji (Author), Xiwen Gu (Author), Xu Guo (Author), Jinliang Xing (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Next-generation sequencing technology has been commonly applied to detect mitochondrial DNA (mtDNA) mutations, which are reported to be strongly associated with cancers. However, several key challenges still exist regarding bioinformatics analysis of mtDNA sequencing data that greatly affect the det...