Utility of denaturing high performance liquid chromatography (DHPLC) for the diagnosis of mevalonate kinase deficiency in periodic fevers of autoinflammatory nature suspicion

• Main Authors: M. Plebani (Author), D. Basso (Author), M. Razetti (Author), M. Miorin (Author), F. Navaglia (Author), A. Furlan (Author), A. Gava (Author), L. Punzi (Author)
• Format: Book
• Published: PAGEPress Publications, 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: We developed a genetic investigation using denaturing high performance liquid chromatography (DHPLC), in order to identify polymorphisms of the gene MVK in patients with autoinflammatory syndrome suspicion. Methods: We evaluated 19 patients affected by recurrent fevers and other clinical...