Development of a highly sensitive method for detection of FLT3D835Y

• मुख्य लेखकों: Yao Guo (लेखक), Honghua Sun (लेखक), Dengyang Zhang (लेखक), Yuming Zhao (लेखक), Mingxia Shi (लेखक), Ming Yang (लेखक), Shu Xing (लेखक), Xueqi Fu (लेखक), Ting Bin (लेखक), Bo Lu (लेखक), Shunjie Wu (लेखक), Xiaojun Xu (लेखक), Xuesong Xu (लेखक), Yun Chen (लेखक), Zhizhuang Joe Zhao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as the most common substitution. This mutation activates survival signals...