Development of a highly sensitive method for detection of FLT3D835Y

• Main Authors: Yao Guo (Author), Honghua Sun (Author), Dengyang Zhang (Author), Yuming Zhao (Author), Mingxia Shi (Author), Ming Yang (Author), Shu Xing (Author), Xueqi Fu (Author), Ting Bin (Author), Bo Lu (Author), Shunjie Wu (Author), Xiaojun Xu (Author), Xuesong Xu (Author), Yun Chen (Author), Zhizhuang Joe Zhao (Author)
• Format: Book
• Published: BMC, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Acute myeloid leukemia (AML) is a malignant hematological neoplasm of myeloid progenitor cells. Mutations of FLT3 in its tyrosine kinase domain (FLT3-TKD) are found in ~ 8% of patients with AML, with D835Y as the most common substitution. This mutation activates survival signals...