Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation

• Main Authors: Jiahong Meng (Author), Chenhe Zhou (Author), Bin Hu (Author), Mengmeng Luo (Author), Yute Yang (Author), Yangxin Wang (Author), Wei Wang (Author), Guangyao Jiang (Author), Jianqiao Hong (Author), Sihao Li (Author), Haobo Wu (Author), Shigui Yan (Author), Weiqi Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aseptic loosening and periprosthetic osteolysis are the leading causes of total joint arthroplasty failure, which occurs as a result of chronic inflammatory response and enhanced osteoclast activity. Here we showed that stevioside, a natural compound isolated from Stevia rebaudiana, exhibited preven...