Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

• Main Authors: Qingfeng Yu (Author), Chengjie Wu (Author), Yeda Chen (Author), Bingsheng Li (Author), Ruixiao Wang (Author), Ru Huang (Author), Xuechun Li (Author), Di Gu (Author), Xiaolong Wang (Author), Xiaolu Duan (Author), Shujue Li (Author), Yang Liu (Author), Wenqi Wu (Author), Martin Hennenberg (Author), Guohua Zeng (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overactive bladder (OAB) is the most bothersome symptom in lower urinary tract symptoms (LUTS). Current pharmacologic treatment aims to inhibit detrusor contraction; however, shows unsatisfied efficacy and high discontinuation rate. LIM kinases (LIMKs) promote smooth muscle contraction in the prosta...