Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

• Main Authors: Bianca E. Suur (Author), Melody Chemaly (Author), Moritz Lindquist Liljeqvist (Author), Djordje Djordjevic (Author), Markus Stenemo (Author), Otto Bergman (Author), Eva Karlöf (Author), Mariette Lengquist (Author), Jacob Odeberg (Author), Eva Hurt-Camejo (Author), Per Eriksson (Author), Daniel F.J. Ketelhuth (Author), Joy Roy (Author), Ulf Hedin (Author), Michael Nyberg (Author), Ljubica Matic (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and druggability potential of the entire PCSK fam...