Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.

• Main Authors: Daisuke Kodama (Author), Masakazu Tanaka (Author), Toshio Matsuzaki (Author), Kimiko Izumo (Author), Nobuaki Nakano (Author), Eiji Matsuura (Author), Mineki Saito (Author), Masahiro Nagai (Author), Masahisa Horiuchi (Author), Atae Utsunomiya (Author), Hiroshi Takashima (Author), Ryuji Kubota (Author), Shuji Izumo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human T-cell leukemia virus type 1 (HTLV-1) causes incurable adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Patients with HAM/TSP have increased levels of HTLV-1-infected cells compared with asymptomatic HTLV-1 carriers. However, the roles of cellular...