Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor

• Главные авторы: Rongrong Deng (Автор), Chenshu Xu (Автор), Xiao Chen (Автор), Pan Chen (Автор), Yongtao Wang (Автор), Xunian Zhou (Автор), Jing Jin (Автор), Lu Niu (Автор), Mengjia Ying (Автор), Min Huang (Автор), Huichang Bi (Автор)
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• Опубликовано: Elsevier, 2014-01-01T00:00:00Z.
• Предметы: article
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Abstract.: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts. The inducible expression of several important cytochrome P450 (CYP450) enzymes has been shown to be regulated by the activation...