Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor

• Main Authors: Rongrong Deng (Author), Chenshu Xu (Author), Xiao Chen (Author), Pan Chen (Author), Yongtao Wang (Author), Xunian Zhou (Author), Jing Jin (Author), Lu Niu (Author), Mengjia Ying (Author), Min Huang (Author), Huichang Bi (Author)
• Format: Knjiga
• Izdano: Elsevier, 2014-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract.: The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is activated by a number of clinically prescribed drugs and herbal extracts. The inducible expression of several important cytochrome P450 (CYP450) enzymes has been shown to be regulated by the activation...