DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis

• Main Authors: Xue-yin Pan (Author), Yang Yang (Author), Hong-wu Meng (Author), Hai-di Li (Author), Xin Chen (Author), Hui-min Huang (Author), Fang-tian Bu (Author), Hai-xia Yu (Author), Qin Wang (Author), Cheng Huang (Author), Xiao-ming Meng (Author), Jun Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activation of hepatic stellate cells (HSCs) is a central event in the progression of liver fibrosis. Multiple studies proved that DNA methylation might accelerate HSCs activation. However, the specific pathogenesis of liver fibrosis remains not fully addressed. Our laboratory performed Genome me...