Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

• Main Authors: Ádám Horváth (Author), Maja Payrits (Author), Anita Steib (Author), Boglárka Kántás (Author), Tünde Biró-Süt (Author), János Erostyák (Author), Géza Makkai (Author), Éva Sághy (Author), Zsuzsanna Helyes (Author), Éva Szőke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sphingo...