P-glycoprotein-dependent pharmacokinetics of irinotecan and its active metabolite, SN-38 in rats: Effect of verapamil
We have recently demonstrated that the oral bioavailability of irinotecan (80 mg/kg) can be increased at least 7-fold by co-administration of the P-gp blocker verapamil (25 mg/kg, Oral). As a result, co-treatment with P-gp inhibitor could be a useful strategy for bioavailability enhancement. However...
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| Main Authors: | , , , |
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| Format: | Book |
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International Association of Physical Chemists (IAPC),
2015-03-01T00:00:00Z.
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A1234.567 |
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