Identification of Keratinocyte Cytoprotectants against Toxicity by the Multikinase Inhibitor Sorafenib Using Drug Repositioning

• Hlavní autoři: Yayoi Kamata (Autor), Rui Kato (Autor), Mitsutoshi Tominaga (Autor), Sumika Toyama (Autor), Eriko Komiya (Autor), Jun Utsumi (Autor), Takahide Kaneko (Autor), Yasushi Suga (Autor), Kenji Takamori (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2024-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Hand-foot skin reaction is the most common adverse event of multikinase inhibitors, such as sorafenib. Although hand-foot skin reaction is not life threatening, severe cases impair quality of life because of pain and reduced activities of daily living. However, the pathological mechanisms of hand-fo...