Identification of Keratinocyte Cytoprotectants against Toxicity by the Multikinase Inhibitor Sorafenib Using Drug Repositioning

• Main Authors: Yayoi Kamata (Author), Rui Kato (Author), Mitsutoshi Tominaga (Author), Sumika Toyama (Author), Eriko Komiya (Author), Jun Utsumi (Author), Takahide Kaneko (Author), Yasushi Suga (Author), Kenji Takamori (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hand-foot skin reaction is the most common adverse event of multikinase inhibitors, such as sorafenib. Although hand-foot skin reaction is not life threatening, severe cases impair quality of life because of pain and reduced activities of daily living. However, the pathological mechanisms of hand-fo...