A multi-omics investigation of tacrolimus off-target effects on a proximal tubule cell-line

• Main Authors: Hassan Aouad (Author), Quentin Faucher (Author), François-Ludovic Sauvage (Author), Emilie Pinault (Author), Claire-Cécile Barrot (Author), Hélène Arnion (Author), Marie Essig (Author), Pierre Marquet (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Tacrolimus, an immunosuppressive drug prescribed to a majority of organ transplant recipients is nephrotoxic, through still unclear mechanisms. This study on a lineage of proximal tubular cells using a multi-omics approach aims to detect off-target pathways modulated by tacrolimus that...